Influence of prior sunlight exposure on ICU mortality - does delirium play a role?

exploring the relationship between sunlight exposure and ICU mortality [1]. Interestingly, less daylight exposure prior to ICU admission was associated with a reduction in ICU mortality. While the authors mention the infl u ence of light on the development of delirium, it is also recognized that delirium is an independent risk factor for death [2-4]. However, the authors did not adjust for delirium. To determine whether sunlight exposure is still associated with ICU mortality when additional adjustments are made for delirium, we performed a similar retrospective cohort study on 2,623 patients admitted to ICUs of three large hospitals in the Netherlands. Th e 28-day photoperiod values were retrieved from weather stations in the vicinity of these hospitals from the Royal Dutch Meteorological Institute, including actual sunlight hours per day. Th e pre-illness photoperiod ranged from 37 to 301 hours. In total, 849 (32.4%) patients suff ered from delirium during their ICU admission and 200 (7.6%) patients died during their hospital stay. In a multivariate logistic regression analysis adjusting for similar covariates to the Castro group but now also including delirium, the cumulative 28-day photoperiod prior to ICU admission was not associated with in-hospital mortality (odds ratio = 1.001; 95% confi dence interval = 0.997 to 1.005). Naturally, our study population is smaller than that in Castro and colleagues’ study and therefore it would be interesting to know whether the reported relationship between sunlight exposure and outcome remains when delirium is added as a covariate. If this relationship does not remain, it could be determined whether delirium is a confounder or a mediator of mortality.